EDIT NOTE: I don't follow, watch or understand anything about the NFL and nor do I care to.
That being said, The League is a fantastic show. Quick synopsis: "The series revolves around six friends who participate in a fantasy football league. The show follows the friends, who will do anything to win, while also dealing with a variety of situations that occur in their everyday lives." -Wikipedia
Why should you watch it? It's hilarious and perfect. How do you know if you'll like it? I don't know, genius - maybe watch an episode and see. I can't really think of any other show to compare it to, since good shows usually stand alone in their greatness. I first gave it a try 'cause I was on a silent Mark Duplass binge for awhile and wanted to see everything he's been apart of, and even after having gotten over that crush, this series still is in my top five of best stuff on television at the moment. (Other stuff on that list? The Mindy Project (I know he's on that show as well, but I swear I'm over him.), Community, Girls, Bob's Burgers.) Give it a watch!
Sidenote: Every single thing that Rafi (Jason Mantzoukas) has ever said on this show has been a gem, Lord love him. The fourth season starts Wednesday September 4th at 10:30pm.